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A randomized trial with adolescents aged 1218 years with severe obesity evaluated the efficacy of topiramate in maintaining weight loss following a 4-week meal-replacement therapy [91].There was no statistically significant difference in percent BMI change between the topiramate and placebo groups after 28 weeks

The concentrations used, the cell types tested, and the exposure conditions do not directly translate to what happens when a human applies a cream or injects a solution

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A nose-poke in the designated active hole triggered the infusion pump to administer a METH infusion, followed by a 20-s time-out period during which additional nose-pokes were recorded but not reinforced